De sykdomsmodifiserende legemidlene brukes gjerne i kombinasjon med symptomlindrende legemidler som betennelsesdempende- og smertestillende legemidler.Noen ganger hovner skiven opp og forårsaker betydelig irritasjon på nerveroten som har sitt utspring i ryggmargen. Dette kan da gi isjias.Mange får feilaktig diagnosen isjias fordi de har utstrål
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